Fully automated cryogen-free analysis of ethylene oxide and 2-chloroethanol in contaminated sesame seeds using headspace–trap with multi-step enrichment (MSE®) GC–MS

High levels of ethylene oxide and 2-chloroethanol present in sesame seeds and other agricultural products have led to multiple product recalls throughout the European Union (EU). Here, we show headspace–trap with multi-step enrichment (MSE) on the Centri^® platform to quantitatively determine the contaminants at the required 0.05 mg/kg (50 ppb) reporting threshold or maximum residue limit without extensive and
manual sample preparation.

Excellent chromatographic performance is shown with the linearities of ethylene oxide and 2-chloroethanol at R² = 0.9983 and R² = 0.9995, respectively, within a single GC–MS analysis, and reproducibility with relative standard deviation ≤ 5%. 

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