Substances with the following hazard properties may be identified as SVHCs:
• Those in categories 1A or 1B of the list defined as being carcinogenic, mutagenic or toxic for reproduction (CMR substances), according to European Commission Regulation (EC) No. 1272/2008.
• Those that are persistent, bioaccumulative and toxic (PBT) or very persistent and very bioaccumulative (vPvB) according to REACH (Annex XIII).
• Those identified on a case-by-case basis, for which there is scientific evidence of probable serious effects that cause an equivalent level of concern to CMR or PBT/vPvB substances.
Key SVHCs include: 2-ethoxyethyl acetate, 2-propenamide, 1-methyl-2-pyrrolidinone, anthracene, benzyl butyl phthalate, bis(2-ethylhexyl) phthalate, dibutyl phthalate, diisoheptyl phthalate, 2-ethoxyethanol, 2-methoxyethanol and 1,2,3-trichloropropane.
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A wide range of substances, both natural and man-made, are thought to disrupt the action of hormone receptors in humans.
These include dioxin and dioxin-like compounds, polychlorinated biphenyls (PCBs), brominated flame retardants, certain pesticides, and components of plastics such as bisphenol A (BPA) and phthalates.
At low doses, EDCs are believed to be linked to adverse effects in humans, including cancer, obesity, type 2 diabetes, low semen quality and genital malformations.
As a result, EDCs are an ongoing challenge for the analytical chemist, and the focus of much current research.